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KMID : 0351619700110020257
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Kyungpook Medical Journal
1970 Volume.11 No. 2 p.257 ~ p.264
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Studies on the Effect of Treated Antigens on the Priming of Antibody response
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Abstract
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In order to know the effect of treated antigens on tile priming of antibody responses, antigens treated with some simple procedures were used for the primary immunization, and then antibody responses in rabbits to enterobacterial common antigen(CA), which is wide1y distributed among enteric bacteria, were determined after secondary immunization with CA.
1. Crude heat-extracted antigen of Salmonella typhimurium(Stm) lost the erythrocyte-modifying activity in slight degrees then filtered with Millipore filter(0.22 micron of pore size) before or after dilution dilution with buffered saline. However, the erythrocyte-modifying activity of CA was lost almost entirely even when filtered after dilution of CA to be 1:5.
2. Stm antigen did not show any priming effect on the secondary response of CA, but CA showed a marked priming effect on the secondary CA antibody response.
3. There was no marked difference on the priming effect between CA and CA filtered before dilution, but CA lost the priming effect when CA was filtered after dilution.
4. There was much difference on the priming effect of CA antibody production between CA and CA filtrate when a large amount was used for the primary injection, and/or when interval between primary and secondary injections was about 2 weeks.
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KEYWORD
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